About
| Name | John A. Means, Ph.D. |
| Title | Professor of Chemistry |
| Alternate Title A | Chemistry/Physics Program Coordinator |
| Alternate Title B | Southern Ohio District 14 Science Day Co-Director |
| Department/School | School of Mathematics & Natural Science |
| Building | |
| Phone | (740) 245-7165 |
| Location | Rio Grande Main Campus |
Office Hours
| Office Hours | varies by term, posted at office door |
Education
| Education | Ph.D., Ohio University, 2007 M.S., The Ohio State University, 2001 B.A., Capital University, 1996 |
Research Information
| Research Interests | Small molecule interactions with nucleic acids Structural biology of nucleic acids Computational methods in the discovery and design of new therapeutic agents |
Publications
| Publications | Mitchell, M. O.; Means, J. Cation-Pi Interactions in Biochemistry: A Primer. J. Chem. Educ. 2018, 95, 2284-2288. Liu, J.; Zeng, C.; Zhou, S.; Means, J. A.; Hines, J. V. Fluorescence assays for monitoring RNA-ligand interactions and riboswitch-targeted drug discovery screening. Methods Enzymol. 2015, 550, 363-383. Zhou, S.; Means, J. A.; Acquaah-Harrison; Bergmeier, S. C.; Hines, J. V. Characterization of a 1,4-disubstituted 1,2,3-triazole binding to T box antiterminator RNA. Bioorg. Med. Chem. 2012, 20 (3), 1298-1302. Orac, C. M.; Zhou, S.; Means, J. A.; Boehm, D.; Bergmeier, S. C.; Hines, J. V. Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA. J. Med. Chem. 2011, 54 (19), 6786-6795. Means, J. A.; Simson, C. M.; Zhou, S.; Rachford, A. A.; Rack, J. J.; Hines, J. V. Fluorescence probing of T box antiterminator RNA: Insights into riboswitch discernment of the tRNA discriminator base. Biochem. Biophys. Res. Comm. 2009, 389 (4), 616-621. Anupam, R.; Nayek, A.; Green, N. J.; Grundy, F. J.; Henkin, T. M.; Means, J. A.; Bergmeier, S. C.; Hines, J. V. 4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function. Bioorg. Med. Chem. Lett. 2008, 18 (12), 3541-3544. Jack, K. D.; Means, J. A.; Hines, J. V., Characterizing riboswitch function: Identification of Mg2+ binding site in T box antiterminator RNA. Biochem. Biophys. Res. Comm. 2008, 370 (2), 306-310. Means, J. A.; Wolf, S.; Agyeman, A.; Burton, J. S.; Simson, C. M.; Hines, J. V., T box riboswitch antiterminator affinity modulated by tRNA structural elements. Chem. Biol. Drug Des. 2007, 69 (2), 139-145. Means, J. A.; Katz, S.; Nayek, A.; Anupam, R.; Hines, J. V.; Bergmeier, S. C., Structure-activity studies of oxazolidinone analogs as RNA-binding agents. Bioorg. Med. Chem. Lett. 2006, 16 (13), 3600-3604. Means, J. A.; Hines, J. V., Fluorescence resonance energy transfer studies of aminoglycoside binding to a T box antiterminator RNA. Bioorg. Med. Chem. Lett. 2005, 15 (8), 2169-2172. |
Interests
| Areas of Expertise | Biochemistry Medicinal Chemistry |