John Means

John Means


About

Name

John A. Means, Ph.D.

Title

Professor of Chemistry

Alternate Title A

Chemistry/Physics Program Coordinator

Alternate Title B

Southern Ohio District 14 Science Day Co-Director

Department/School

School of Mathematics & Natural Science

Email

jmeans@rio.edu

Building

Kidd Math Science Center

Phone

(740) 245-7165

Location

Rio Grande Main Campus

Office Hours

Office Hours

varies by term, posted at office door

Education

Education

Ph.D., Ohio University, 2007

M.S., The Ohio State University, 2001

B.A., Capital University, 1996

Research Information

Research Interests

Small molecule interactions with nucleic acids

Structural biology of nucleic acids

Computational methods in the discovery and design of new therapeutic agents

Publications

Publications

Mitchell, M. O.; Means, J. Cation-Pi Interactions in Biochemistry: A Primer. J. Chem. Educ. 2018, 95, 2284-2288.

Liu, J.; Zeng, C.; Zhou, S.; Means, J. A.; Hines, J. V. Fluorescence assays for monitoring RNA-ligand interactions and riboswitch-targeted drug discovery screening. Methods Enzymol. 2015, 550, 363-383.

Zhou, S.; Means, J. A.; Acquaah-Harrison; Bergmeier, S. C.; Hines, J. V. Characterization of a 1,4-disubstituted 1,2,3-triazole binding to T box antiterminator RNA. Bioorg. Med. Chem. 2012, 20 (3), 1298-1302.

Orac, C. M.; Zhou, S.; Means, J. A.; Boehm, D.; Bergmeier, S. C.; Hines, J. V. Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA. J. Med. Chem. 2011, 54 (19), 6786-6795.

Means, J. A.; Simson, C. M.; Zhou, S.; Rachford, A. A.; Rack, J. J.; Hines, J. V. Fluorescence probing of T box antiterminator RNA: Insights into riboswitch discernment of the tRNA discriminator base. Biochem. Biophys. Res. Comm. 2009, 389 (4), 616-621.

Anupam, R.; Nayek, A.; Green, N. J.; Grundy, F. J.; Henkin, T. M.; Means, J. A.; Bergmeier, S. C.; Hines, J. V. 4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function. Bioorg. Med. Chem. Lett. 2008, 18 (12), 3541-3544.

Jack, K. D.; Means, J. A.; Hines, J. V., Characterizing riboswitch function: Identification of Mg2+ binding site in T box antiterminator RNA. Biochem. Biophys. Res. Comm. 2008, 370 (2), 306-310.

Means, J. A.; Wolf, S.; Agyeman, A.; Burton, J. S.; Simson, C. M.; Hines, J. V., T box riboswitch antiterminator affinity modulated by tRNA structural elements. Chem. Biol. Drug Des. 2007, 69 (2), 139-145.

Means, J. A.; Katz, S.; Nayek, A.; Anupam, R.; Hines, J. V.; Bergmeier, S. C., Structure-activity studies of oxazolidinone analogs as RNA-binding agents. Bioorg. Med. Chem. Lett. 2006, 16 (13), 3600-3604.

Means, J. A.; Hines, J. V., Fluorescence resonance energy transfer studies of aminoglycoside binding to a T box antiterminator RNA. Bioorg. Med. Chem. Lett. 2005, 15 (8), 2169-2172.

Interests

Areas of Expertise

Biochemistry

Medicinal Chemistry

Share This