John Means

John Means



John A. Means, Ph.D.


Professor of Chemistry

Alternate Title A

Chemistry/Physics Program Coordinator

Alternate Title B

Southern Ohio District 14 Science Day Co-Director


School of Natural & Social Sciences



Kidd Math Science Center


(740) 245-7165


Rio Grande Main Campus

Office Hours

Office Hours

varies by term, posted at office door



Ph.D., Ohio University, 2007

M.S., The Ohio State University, 2001

B.A., Capital University, 1996

Research Information

Research Interests

Small molecule interactions with nucleic acids

Structural biology of nucleic acids

Computational methods in the discovery and design of new therapeutic agents



Mitchell, M. O.; Means, J. Cation-Pi Interactions in Biochemistry: A Primer. J. Chem. Educ. 2018, 95, 2284-2288.

Liu, J.; Zeng, C.; Zhou, S.; Means, J. A.; Hines, J. V. Fluorescence assays for monitoring RNA-ligand interactions and riboswitch-targeted drug discovery screening. Methods Enzymol. 2015, 550, 363-383.

Zhou, S.; Means, J. A.; Acquaah-Harrison; Bergmeier, S. C.; Hines, J. V. Characterization of a 1,4-disubstituted 1,2,3-triazole binding to T box antiterminator RNA. Bioorg. Med. Chem. 2012, 20 (3), 1298-1302.

Orac, C. M.; Zhou, S.; Means, J. A.; Boehm, D.; Bergmeier, S. C.; Hines, J. V. Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA. J. Med. Chem. 2011, 54 (19), 6786-6795.

Means, J. A.; Simson, C. M.; Zhou, S.; Rachford, A. A.; Rack, J. J.; Hines, J. V. Fluorescence probing of T box antiterminator RNA: Insights into riboswitch discernment of the tRNA discriminator base. Biochem. Biophys. Res. Comm. 2009, 389 (4), 616-621.

Anupam, R.; Nayek, A.; Green, N. J.; Grundy, F. J.; Henkin, T. M.; Means, J. A.; Bergmeier, S. C.; Hines, J. V. 4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function. Bioorg. Med. Chem. Lett. 2008, 18 (12), 3541-3544.

Jack, K. D.; Means, J. A.; Hines, J. V., Characterizing riboswitch function: Identification of Mg2+ binding site in T box antiterminator RNA. Biochem. Biophys. Res. Comm. 2008, 370 (2), 306-310.

Means, J. A.; Wolf, S.; Agyeman, A.; Burton, J. S.; Simson, C. M.; Hines, J. V., T box riboswitch antiterminator affinity modulated by tRNA structural elements. Chem. Biol. Drug Des. 2007, 69 (2), 139-145.

Means, J. A.; Katz, S.; Nayek, A.; Anupam, R.; Hines, J. V.; Bergmeier, S. C., Structure-activity studies of oxazolidinone analogs as RNA-binding agents. Bioorg. Med. Chem. Lett. 2006, 16 (13), 3600-3604.

Means, J. A.; Hines, J. V., Fluorescence resonance energy transfer studies of aminoglycoside binding to a T box antiterminator RNA. Bioorg. Med. Chem. Lett. 2005, 15 (8), 2169-2172.


Areas of Expertise


Medicinal Chemistry

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